Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene
Human pluripotent stem cells (hPSCs) hold great promise for cell therapy.However, a major concern is the risk of tumor formation by residual undifferentiated cells contaminating the hPSC-derived cell product.Suicide genes could safeguard against such adverse events by enabling elimination Interface Card of cells gone astray, but the efficacy of thi